A Systems Biology Approach to identifying drug targets and predicting therapeutic outcomes in MDS and AML
Location:The Centenary Institute, Lecture Theatre, Level 6, Building 93, Royal Prince Alfred Hospital Grounds
Professor Stephen Turner, Monash University
Professor Stephen Turner is currently a NHMRC Principal Research Fellow and Chair, Department of Microbiology, Monash University. He was awarded his PhD in Viral Immunology from Monash University in 1997. He completed postdoctoral training with Dr Janet Ruby (University of Melbourne) studying pox viral pathogenesis, and then with Nobel Laureate, Professor Peter Doherty (St Jude Children's Research Hospital, USA) studying influenza virus-specific T cell immunity. He returned to the University of Melbourne in 2002, was awarded a NHMRC RD Wright Fellowship in 2005 establishing his own research group. He was awarded a Pfizer Australia Senior Research Fellowship in 2007, an ARC Future Fellowship in 2012, and is currently CIA on a NHMRC program grant that focuses on T cell immunity to influenza. His research interests utilize a combination of structural biology, genomics, systems biology, recombinant viral technology and cellular immunology to examine molecular factors that impact T cell responses to virus infection.
Cardinal features of adaptive T cell immunity include the ability to differentiate in response to infection, resulting in acquisition of lineage-specific functions; and the ability to maintain this functional capacity in the long-term, allowing more rapid and effective pathogen elimination following re-infection. There is great interest in understanding how epigenetic mechanisms contribute to acquisition and maintenance of T cell immune function in response to an immune challenge. Indeed, T cell responses to infection are an ideal model system for studying how epigenetic factors shape cellular differentiation and development generally. This talk will examine how epigenetic mechanisms, and in particular histone PTMs, appear to regulate T cell function and lineage differentiation in response to infection, and how these model systems are providing general insights into the epigenetic regulation of gene transcription during cellular differentiation.
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