Sydney West Translational Cancer Research Centre
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Dr Carlos Salomon: Extracellular vesicles everywhere - Potential diagnostic tools and therapeutic interventions

Special CCR seminar

Jul
26
1
00
P
2
00
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Location:

The Westmead Institute for Medical Research (WIMR Hall)

Special CCR seminar this Thursday, the 26th July from Dr Carlos Salomon- from the University of Queensland Centre for Clinical Research (UQCCR), a potential collaborator for CCR.
Dr Carlos Salomon has trained in Chile, Spain and at the University of Texas Health Science Centre, San Antonio, Texas and now heads the Exome Biology group at UQCCR.

His group explores the role of exosomes under normal and pathological conditions - so as to evaluate their clinical utility as biomarkers of disease and therapeutic interventions. He is well known in the field of extracellular vesicles in reproductive biology and has over 70 publications. EXOSOME BIOLOGY LABORATORY (EBL) Salomon’s group: https://clinical-research.centre.uq.edu.au/salomon-group

Abstract

The past decade has observed an extraordinary explosion of research in the field of extracellular vesicles (EVs), especially in a specific type of EVs originating from endosomal compartments, called exosomes. Exosomes are a specific subtype of secreted vesicles which are defined as small (~30-120 nm) but very stable membrane vesicles that are released from a wide range of cells, including placental and cancer cells. As the content of exosomes is cell type specific, it is believed that it is a “fingerprint” of the releasing cell and its metabolic status. I hypothesize that the exosomes and their specific exosomal content (e.g. miRNAs and proteins) represent a precious biomedical tool, and may be used as biomarkers for the diagnosis and prognosis of a wide range of diseases including complication of pregnancies and malignant tumors. Exosomes may engage in paracellular interactions (i.e. local cellto-cell communication between the cells) and/or distal interactions (i.e. involving the release of placental or tumor exosomes into biological fluids and transportation to a remote site of action). The mechanisms involved in this phenomenon remain unclear, however, inhibition of signaling mediators by exosomes or exosome release may reduce their intracellular bioavailability to the parent cell thereby altering cell phenotype and biological function. The aim of the EBL, thus, is to analysis the biogenesis and role of exosomes from placental cells and tumor cells (focusing primarily on ovarian cancer). Poor pregnancy outcome, resulting from a complication of pregnancy is the single most important modifiable risk factor for reducing the current health epidemics of obesity, cardiovascular diseases and diabetes. Ovarian cancer is the most lethal gynaecological cancer and an effective early diagnosis is critical with potential to improve patient survival.