Dr Robert Hume: Recapitulating breast cancer progression in vitro using adipocyte-invested engineered collagen scaffolds
Centre for Cancer Research Seminar
Location:WIMR Conference Rooms, level 2
Aggressive breast cancer is surrounded by directional collagen fibres. To recapitulate this phenotype in vitro, a novel 3D organotypic ice-templating technique was developed by Dr Hume and his colleagues. Breast cancer cell lines and biopsy material from tumors were seeded into the collagen scaffolds in the model, to study cell migration and response to inhibitors.
Rob Hume studied Biomaterial Science and Tissue Engineering for both undergraduate and masters' degrees at the University of Sheffield in the UK. His PhD investigated breast cancer cells in the context of 3D tissue engineered constructs. He has recently moved to WIMR to now work in Dr. James Chong's laboratory in the Centre for Heart Research, however, in this seminar he will be presenting the data from his PhD that is highly relevant for all of us at CCR.