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Prof Ian Hickson: Genomic instability and cancer: lessons from analysis of chromosome fragile sites



Children's Medical Research Institute Seminar Room

Prof Ian Hickson, Professor and Director of Center for Chromosome Stability, Fellow of the Royal Society, Department of Cellular and Molecular Medicine, University of Copenhagen

Prof Ian Hickson will be visiting CMRI this Friday 16 February. Ian is a professor and director of the Center for Chromosome Stability at the University of Copenhagen and a fellow of the Royal Society. He is visiting Australia as an invited international speaker for the Lorne Genome conference. There are a long list of achievements in Ian’s career related to the study of DNA repair and DNA replication stress. This started with his identification of the E. coli rec B and C products (Nature 1981, any many subsequent follow-up papers). He then moved into mammalian systems and characterized of a series of cells lines of varying resistance or sensitivity to DNA damaging agents (throughout the 1980s), resulting in the identification of a number of DNA repair enzymes that regulated the underlying sensitivity/resistance. The most famous of these discoveries was the Hickson lab’s identification of the BLM gene (Cell 1995), mutation of which causes Blooms Syndrome, and his lab’s subsequent identification that BLM is a DNA helicase that unwinds G4 structures (series of JBC papers 1997-1998), promotes branch migration and suppresses cross over in homologous recombination (PNAS 2000, Nature 2003), and functions in replication stress repair (Nature Struc Mol Bio 2007). His lab has more recently turned their attention to the connection of replication stress and mitosis, discovering ultrafine bridges (Nature Cell Biology 2009), the transmission of replication stress through cell division (Nat Cell Bio 2011), and the discovery of replication stress repair in mitosis (Nature 2015, follow up Molecular Cell 2016).

Host: Tony Cesare