Sydney West Translational Cancer Research Centre
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Prof Sue Clark: Alterations in the Cancer Epigenome

Oct
11
12
30
P
1
30
P

Location:

Children's Medical Research Institute Seminar Room

Professor Sue Clark. Head of the Epigenetics Laboratory, Fellow of the Australian Academy of Science, Garvan Institute of Medical Research

Host: Tony Cesare

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. However it is still unclear if the epigenome is involved in shaping the three-dimensional (3D) chromatin architecture and how this is altered in cancer. Our studies provides new insights into the relationship between long-range epigenetic deregulation and changes in higher-order chromatin interactions in cancer.